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KMID : 1161420150180010128
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Journal of Medicinal Food
2015 Volume.18 No. 1 p.128 ~ p.136
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Great Heterogeneity of Commercial Fruit Juices to Induce Endothelium-Dependent Relaxations in Isolated Porcine Coronary Arteries: Role of the Phenolic Content and Composition
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Auger Cyril
Pollet Brigitte
Arnold Cecile
Marx Celine
Schini-Kerth Valerie B.
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Abstract
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Since polyphenol-rich products such as red wine, grape juice, and grape extracts have been shown to induce potent endothelium-dependent relaxations, we have evaluated whether commercial fruit juices such as those from berries are also able to induce endothelium-dependent relaxations of isolated coronary arteries and, if so, to determine whether this effect is related to their phenolic content. Among the 51 fruit juices tested, 2/12 grape juices, 3/7 blackcurrant juices, 4/5 cranberry juices, 1/6 apple juices, 0/5 orange juices, 2/6 red fruit and berry juices, 3/6 blends of red fruit juices, and 0/4 non-red fruit juices were able to induce relaxations achieving more than 50% at a volume of 1%. The active fruit juices had phenolic contents ranging from 0.31 to 1.86?g GAE/L, which were similar to those of most of the less active juices with the exception of one active grape juice (2.14?g GAE/L) and one active blend of red fruit juices (3.48?g GAE/L). Altogether, these findings indicate that very few commercial fruit juices have the ability to induce potent endothelium-dependent relaxations, and that this effect is not related to their quantitative phenolic content, but rather to their qualitative phenolic composition.
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KEYWORD
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endothelial function, fruit juice, polyphenols, vasorelaxation
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